human energy boost

Three amazing caffeine substitutes for quick and clean energy — and the science behind them

If you’re like the vast majority of Americans, you probably consume caffeine every day of your adult life.

The question is, do you do it because you like it, or because you need it?

In a March 2022 survey by the International Food Information Council (IFIC), respondents over the age of 65 generally said they drink caffeinated beverages because they like the taste, while those under 45 People were more likely to report taking caffeine just for health – a known benefit as a stimulant.[1]

But those benefits are part of the trade-off, and if you don’t actually care about the taste — or even if you do, it’s probably not worth it.

Reasons to Avoid Caffeine

While caffeine can certainly boost your energy levels and improve physical and mental performance, it can also make you jittery — once the infamous “caffeine crash” begins — severely fatigued.

Insomnia, high blood pressure, palpitations, headaches, dizziness, stomach upset and anxiety are the most common side effects of caffeine, and daily use also risks building tolerance (so you need more and more to feel the same revitalizing effect) or addiction, which It can also mean withdrawal symptoms.

Fortunately, there are some great, all-natural caffeine substitutes available on the market today that can give you similar energy and performance boosts, but in a healthier way – so no stress, no Crashes and doesn’t get addicted either.

Here are three of the best, an overview of the science behind them:


Zynamite is a patented extract developed by Spanish nutraceutical company Nektium and commercialized in 2018 mango (Mango tree) Leaf wowed the judges at the 2018 NutraIngredients Awards, winning Ingredient of the Year in the Sports Nutrition category for its scientifically proven “capable of replacing caffeine without any of the typical side effects”.[2]

Unlike other mango leaf extracts, Zynamite is standardized to contain at least 60% mangiferin, which is able to cross the blood-brain barrier and upregulate dopamine in a manner similar to caffeine, but without blocking adenosine receptors this goal[3] – Mechanisms responsible for caffeine benefits and side effects.

Conversely, mangiferin inhibits the enzyme catechol-O-methyltransferase (COMT), which breaks down dopamine in the prefrontal cortex,[4] This raises dopamine levels without causing a buildup of adenosine, which normally causes a caffeine crash.[5]

A 2020 study led by Professor David Kennedy, Director of the Centre for Brain, Performance and Nutrition at Northumbria University, UK, found that a single dose of Zynamite in healthy adults resulted in significant improvements of up to 6 hours – author of the study Noting that the cognitive benefits were “broader and longer-lasting than expected after caffeine.”[6]

Early clinical studies have also found that a single dose of Zynamite in combination with the common plant flavonoids quercetin or luteolin can enhance athletic performance by increasing muscle oxygen extraction and brain oxygenation[7,8] And accelerate muscle recovery during exercise.[9]


Another award-winning caffeine alternative is EnXtra, a proprietary extract Galangal (Galanga – Zingiberaceae), developed by Mumbai-based Enovate Biolife, won Ingredient of the Year in the Sports Nutrition and Cognitive Function categories at the 2019 NutraIngredients Awards and the 2021 NutraIngredients-USA Awards, respectively.[10]

EnXtra works in much the same way as caffeine, inhibiting adenosine receptors and inhibiting dopamine reuptake, but with one key difference: while caffeine is a vasoconstrictor, it increases blood pressure and reduces blood flow to the brain — in layman’s terms , the main cause of caffeine’s unpleasant cardiovascular side effect is known as jitter — EnXtra had no adverse effect on blood circulation or heart rate.[11]

In fact, even in areas where caffeine excels as a stimulant—improving mental alertness, energy, focus, and focus—EnXtra outperforms its competitors, with its Galangal Extract no less than eight known dopaminergic biological compounds[12] Work together to deliver superior and long-lasting neurostimulator benefits.

Recent research finds that EnXtra consistently increases alertness[13] and focus[14] over five hours, while the caffeine temporarily boosted scores in those areas before causing a breakdown in about three hours.

Unlike caffeine, which generally exhibits a “ceiling effect”, where tolerance builds rapidly, the chemical provides no further benefit even after a short period of sustained (i.e. daily) light to moderate use, EnXtra “demonstrated a sustained increase in acute alertness and no decline during 180 days of use, according to a long-term safety and efficacy study conducted in 2019.[11]

The results of the safety study also showed that there were no withdrawal symptoms associated with withdrawal after taking EnXtra twice daily for an extended period of time – unlike caffeine.


Described as “a patented compound that provides energy, mental clarity, improved motivation and mood”,[15] TeaCrine was developed by California-based nutraceutical company Compound Solutions and first commercialized in 2015.

TeaCrine is structurally similar to caffeine and therefore acts via the same dopaminergic and adenosinergic pathways, but with a half-life of approximately 20 hours – much longer than caffeine’s half-life of approximately 5 hours[16] – So stay active in the blood longer.

TeaCrine’s adenosine activity is also slightly different compared to caffeine; while caffeine completely blocks adenosine receptors — which leads to a buildup of chemical sleep signals that eventually overwhelm the brain, leading to the familiar crashing effect of caffeine — TeaCrine is much less antagonistic, preventing sudden collapse.[17]

An early pilot study found that within six hours of a single dose, TeaCrine significantly reduced fatigue and anxiety, while significantly increasing energy, motivation, libido, and focus,[18] It is therefore proven that its effect is more durable than that of caffeine.

A later safety study also found that TeaCrine had no apparent effect on heart rate or blood pressure, might actually lower cholesterol levels, and – crucially, unlike caffeine – had no habit at all.[19]

final thoughts

Many people enjoy caffeinated beverages, but if you’re one of a growing number of people who drink caffeine just for health and performance, the side effects of caffeine may not be worth it.

Even if you do enjoy caffeinated beverages like coffee or energy drinks, you may still be keen to find a less addictive alternative, one that doesn’t put your long-term health at risk.

Fortunately, the caffeine substitute market is exploding right now, and nutraceuticals like Zynamite, EnXtra, and TeaCrine have real science to back up their claimed effectiveness.

With these products clinically proven to boost energy and focus – just like caffeine, and in many cases even better than caffeine – without causing jitters, breakdowns, tolerance or addiction, the world’s most popular Welcome stimulants could soon be a thing of the past?

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