UK study finds HPV vaccine reduces cervical cancer incidence in women by 87%

Nearly half of global cancer deaths can be attributed to preventable risk factors, new study shows

“To our knowledge, this study is the largest effort to date to identify the global cancer burden attributable to risk factors, and it contributes to a growing body of evidence aimed at estimating domestic, international and global ,” Dr. Chris Murray, director of the Institute for Health Metrics and Evaluation at the University of Washington, and colleagues wrote in the study.

The paper, funded by the Bill and Melinda Gates Foundation, used data from the Institute for Health Metrics and Evaluation’s Global Burden of Disease Project to analyze the relationship between risk factors and cancer, the second leading cause of death worldwide.

The project collects and analyzes global data on death and disability. Murray and his colleagues studied cancer death and disability in 204 countries from 2010 to 2019, examining 23 cancer types and 34 risk factors.

number one cancers The researchers found that in terms of global risk-attributable deaths in 2019, both men and women were cancers of the trachea, bronchus and lung.

The data also showed an upward trend in risk-attributable cancer deaths, increasing by 20.4% globally from 2010 to 2019. Globally, the top five regions for risk-attributable mortality in 2019 were Central Europe, East Asia, North America, Southern Latin America, and Western Europe.

“These findings highlight that a significant portion of the global cancer burden is potentially preventable by interventions aimed at reducing known cancer risk factors, but that a significant portion of the cancer burden may not be avoided by controlling for currently estimated risk factors,” the researchers said. wrote. “As such, efforts to reduce cancer risk must be coupled with comprehensive cancer control strategies, including efforts to support early diagnosis and effective treatment.”

Dr. William Dahout, chief scientific officer of the American Cancer Society, who was not involved in the new study, wrote in an email to CNN.

“Behavioural changes could potentially save millions of lives, largely overshadowing the effects of any approved drug,” he wrote, adding, “Despite an approximately 65-year link to cancer, the persistent effects of tobacco remain. Very problematic.”

Even though tobacco use in the U.S. is lower than in other countries, tobacco-related cancer deaths remain a major problem and disproportionately impact some states, Dahut wrote.

Study finds prolonged sitting increases cancer risk
Another study, published earlier this month in the International Journal of Cancer, found that among adults aged 25 to 79, the estimated proportion of cancer deaths due to smoking in 2019 ranged from 16.5% in Utah to Kentucky 37.8% in states. Estimates of total lost revenue from cancer deaths from smoking ranged from $32.2 million in Wyoming to $1.6 billion in California.

“Furthermore, it’s no secret that alcohol consumption, along with dramatic increases in median BMI, will lead to massive preventable cancer deaths,” Dahut added. “Finally, as we move into a world where screening is precision-based and adaptable, cancer screening is especially important for those at increased risk.”

Preventable risk factors associated with cancer are often associated with poverty, wrote Dr Diana Safarti and Jason Gurney of the Te Aho o Te Kahu Cancer Control Facility in New Zealand in an editorial published alongside the new Lancet study.

“Poverty affects the environments in which people live, and those environments determine the lifestyle decisions people are able to make. Actions to prevent cancer require concerted efforts within and outside the health sector. This action includes specific policies aimed at reducing exposure to cancer – leading to risk factors, such as smoking and alcohol consumption, and access to vaccines to prevent cancer-causing infections, including hepatitis B and HPV,” Safati and Gurney wrote.

“Preventing cancer by eradicating or mitigating modifiable risk factors is our best hope for reducing the future burden of cancer,” they wrote. “Reducing this burden will improve health and well-being, and reduce the compounding impact on humans and cancer services and Financial resource pressures on the wider health sector.”

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